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TP53 and ovarian cancer
Author(s) -
Schuijer Monique,
Berns Els M.J.J.
Publication year - 2003
Publication title -
human mutation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 162
eISSN - 1098-1004
pISSN - 1059-7794
DOI - 10.1002/humu.10181
Subject(s) - ovarian cancer , serous fluid , chemotherapy , cancer , oncology , biology , disease , medicine , cisplatin , cytoreductive surgery , cancer research , bioinformatics
Abstract Ovarian cancer represents the fourth most frequent type of cancer among females and is the leading cause of death from gynecological cancer in the western world. This review describes gene alterations in ovarian cancer. Specific emphasis is placed on genetic alterations and the prevalence of TP53 (p53) gene alterations in the distinct biological ovarian tumors (benign, borderline, and malignant) and histological subtypes (serous, mucinous, endometrioid, clear cell), as well as in BRCA1‐associated hereditary ovarian cancer. Although multi‐modality treatment regimens, including cytoreductive surgery and cisplatin‐containing combination chemotherapy, have usefully prolonged survival, the overall cure rate of the disease has not changed dramatically. Ovarian cancer is difficult to eradicate completely by surgery and many patients have only a partial response to postoperative chemotherapy and/or many will develop chemotherapy resistance. All these important factors contribute to the poor prognosis of ovarian cancer patients. In this review, the putative prognostic or predictive value of TP53 in ovarian cancer is addressed. Hum Mutat 21:285–291, 2003. © 2003 Wiley‐Liss, Inc.