Open AccessInvestigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM Ⓡ ): A retrospective study
Author(s) -
Matsuoka Ayaka,
Koami Hiroyuki,
Shinada Kota,
Sasaki Akira,
Yamazaki Hirotaka,
Mori Kosuke,
Nakayama Kento,
Asahi Miho,
Yoshitake Kunimasa,
Narumi Shogo,
Koba Mayuko,
Kawaguchi Atsushi,
Sakamoto Yuichiro
Publication year - 2022
Publication title -
health science reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 7
ISSN - 2398-8835
DOI - 10.1002/hsr2.655
Subject(s) - thromboelastometry , medicine , logistic regression , odds ratio , receiver operating characteristic , coagulopathy , prothrombin time , retrospective cohort study , thrombelastography , covid-19 , confidence interval , area under the curve , surgery , anesthesia , coagulation , disease , infectious disease (medical specialty)
Background Hemorrhagic complications in patients with coronavirus 19 disease (COVID‐19) are infrequent but associated with a prognosis. This study aimed to elucidate the risk factors for bleeding complications in patients with COVID‐19 using rotational thromboelastometry (ROTEM) parameters and blood tests performed at admission. Methods In total, 31 patients with severe COVID‐19 treated intensively at Saga University Hospital were included in this study. Patients were divided into two groups according to the presence or absence of hemorrhagic complications. Results from the blood tests performed at admission and during hospitalization, and ROTEM values acquired upon admission, were compared between the two groups. Results There were significant differences in ROTEM values upon admission between the bleeding and non‐bleeding groups. Receiver operating curve analysis showed that the area under the curve for prothrombin time international normalized ratio (PT‐INR) and extrinsically‐activated test with tissue factor (EXTEM) amplitude at 10 min (A10) were 0.82 (0.52–0.92) and 0.81 (0.58–0.93), respectively. Logistic regression analysis with PT‐INR and EXTEM A10 as factors calculated an odds ratio of 1.94 (1.04–3.62) and EXTEM A10 0.86 (0.71–1.05) for bleeding complications occurrence. Conclusion ROTEM may be a sensitive predictor for bleeding complications in patients with COVID‐19.