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Use of DNA sequencing for noncommunicable diseases in low‐income and middle‐income countries' primary care settings: A narrative synthesis
Author(s) -
GonzálezRobledo Luz Maria,
ServánMori Edson,
CasasLópez Anaid,
FloresHernández Sergio,
Bravo María Lilia,
SánchezGonzález Gilberto,
Nigenda Gustavo
Publication year - 2018
Publication title -
the international journal of health planning and management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 41
eISSN - 1099-1751
pISSN - 0749-6753
DOI - 10.1002/hpm.2698
Subject(s) - low and middle income countries , health care , public health , business , primary care , economic growth , developed country , developing country , medicine , environmental health , family medicine , nursing , economics , population
Summary Objective To present a systematic narrative review, informed by international experience, on the use of genomic analysis technologies in the primary care of noncommunicable chronic diseases (NCDs) during the last 20 years. Methods We used the methodology for conducting systematic reviews proposed by the Center for Coordination and Information on Evidence for Policies and Practices. The selected articles were organized by time, place, study design, and type of DNA sequencing. Finally, we analyzed the implications of our findings for health systems in middle‐income and low‐income countries focusing on a NCD high prevalence country such as México. Results Evidence concerning the use of DNA sequencing in primary care for NCDs was scarce and geographically concentrated in high‐income countries. Use was limited by costs, insufficient knowledge among health care personnel, and a lack of confidence on the part of users. Conclusions The use of DNA sequencing for primary care of NCDs is a challenge for low‐ and middle‐income countries. More evidence is needed on cost effectiveness, public funding mechanisms, and the training of health care personnel for its implementation.