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18 F‐FDG uptake and its clinical relevance in primary gastric lymphoma
Author(s) -
Yi Jun Ho,
Kim Seok Jin,
Choi Joon Young,
Ko Young Hyeh,
Kim ByungTae,
Kim Won Seog
Publication year - 2010
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.905
Subject(s) - medicine , lymphoma , standardized uptake value , stage (stratigraphy) , nuclear medicine , positron emission tomography , gastric lymphoma , radiology , stomach , endoscopy , clinical significance , lesion , pathology , gastroenterology , paleontology , biology
We studied the clinical relevance of 18 F‐fluorodeoxyglucose ( 18 F‐FDG) uptake in patients with primary gastric lymphoma underwent positron emission tomography (PET)/ computed tomography (CT) scan. Forty‐two patients with primary gastric lymphoma were analysed: 32 diffuse large B‐cell lymphomas (DLBCL) and 10 extranodal marginal zone B‐cell lymphomas of mucosa‐associated lymphoid tissue (MALT lymphomas). The PET/CT scans were compared with clinical and pathologic features, and the results of CT and endoscopy. Nine patients were up‐staged based on the results of their PET/CT scan compared to CT (seven DLBCLs, two MALT lymphomas) while six patients were down‐staged by the PET/CT scan. The standard uptake value (SUV) was used as an indicator of a lesion with a high metabolic rate. The high SUVmax group, defined as an SUVmax ≥ median value, was significantly associated with an advanced Lugano stage ( p < 0.001). Three patients with DLBCL, who showed an initially high SUVmax, died of disease progression. Among 24 patients for whom follow‐up PET/CT scan with endoscopy was performed, 11 patients with ulcerative or mucosal lesions showed residual 18 F‐FDG uptake. All of these gastric lesions were grossly and pathologically benign lesions without evidence of lymphoma cells. In conclusion, PET/CT scan can be used in staging patients with primary gastric lymphoma; however, the residual 18 F‐FDG uptake observed during follow‐up should be interpreted cautiously and should be combined with endoscopy and multiple biopsies of the stomach. Copyright © 2009 John Wiley & Sons, Ltd.