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Involved field radiotherapy for limited stage Hodgkin lymphoma: balancing treatment efficacy against long‐term toxicities
Author(s) -
Goda Jayant S.,
Tsang Richard W.
Publication year - 2009
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.890
Subject(s) - medicine , radiation therapy , lymphoma , stage (stratigraphy) , disease , hodgkin lymphoma , chemotherapy , oncology , modality (human–computer interaction) , intensive care medicine , paleontology , human–computer interaction , computer science , biology
Abstract Limited stage Hodgkin lymphoma (HL) refers to patients with stage IA or IIA disease in the absence of any bulky mass or unfavourable prognostic factors. In this group, the long‐term disease control with treatment can be expected in more than 90%, and management has now been directed to make strategies to reduce late morbidities related to therapy. With the advent of very effective chemotherapy, the role of radiation therapy has evolved from a first line single modality treatment, to an adjuvant therapy following brief cycles of chemotherapy. Optimal radiation volume and dose parameters have been refined in the combined modality setting. Furthermore, with the progress in diagnostic functional imaging and advances in radiotherapy, it is possible to accurately deliver low to moderate doses of radiation to defined regions resulting in durable control of disease. This review will evaluate the literature that shapes the current standard of care in limited stage Hodgkin lymphoma with special emphasis on the use of limited field radiotherapy. Copyright © 2009 John Wiley & Sons, Ltd.