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The role of stem cell transplantation in the management of chronic lymphocytic leukaemia
Author(s) -
Tam Constantine S.,
Khouri Issa
Publication year - 2009
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.884
Subject(s) - medicine , transplantation , stem cell , chronic lymphocytic leukemia , disease , treatment modality , oncology , intensive care medicine , leukemia , genetics , biology
The majority of patients diagnosed with chronic lymphocytic leukaemia (CLL) will ultimately die of their disease. Stem cell transplantation (SCT) remains the only treatment modality capable of cure, but has traditionally been associated with very high morbidity and mortality. We review the results of myeloablative autologous and allogeneic SCT in CLL, discuss the evolution of the new non‐myeloablative approaches, and make recommendations for when SCT should be considered in patients with CLL. Copyright © 2009 John Wiley & Sons, Ltd.