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Senile EBV‐associated B‐cell lymphoproliferative disorder of prepatellar bursa in an elderly patient with multifocal urate arthropathy
Author(s) -
Mueller Susanna,
Aigner Thomas,
Haag Jochen,
Schwarz Rene,
Niedobitek Gerald
Publication year - 2007
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.814
Subject(s) - medicine , gout , lymphoproliferative disorders , immunology , arthropathy , epstein–barr virus , b cell , virus , pathology , antibody , lymphoma , osteoarthritis , alternative medicine
Abstract We report a case of an EBV‐associated high grade B‐cell lymphoproliferative disorder occurring in the synovial membrane of an elderly patient with gout arthropathy. The EBV‐infected B‐cells displayed a pattern of viral gene expression (EBNA2 + /LMP1 + ) typically seen during primary EBV‐infection and in lymphoproliferations occurring in immunosuppressed individuals. This case conforms to senile EBV‐associated lymphoproliferative disorders previously reported only in Japanese patients. We suggest that an impaired EBV‐specific T‐cell immunity, local or systemic, may play a role in the development of this disorder and that chronic diseases such as gout may be contributing factors. Copyright © 2007 John Wiley & Sons, Ltd.