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Review: new biological insights in early clinical studies
Author(s) -
Maur Michela,
Sessa Cristiana
Publication year - 2007
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.808
Subject(s) - clinical trial , drug development , gateway (web page) , medicine , computer science , drug , pharmacology , pathology , world wide web
First in human phase I trials are an unaviodable gateway to the development of new anticancer therapies. The discovery of target therapies have significantly changed the process of clinical drug development. This short review will focus on the main features including knowledge of biological aspects, methodology and adequacy of design and of performance of early clinical studies. Copyright © 2007 John Wiley & Sons, Ltd.