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Bone marrow and tumour stroma: an intimate relationship
Author(s) -
Direkze Natalie C,
Alison Malcolm R
Publication year - 2006
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.788
Subject(s) - bone marrow , stroma , haematopoiesis , pathology , medicine , biology , stem cell , cancer research , microbiology and biotechnology , immunohistochemistry
In recent years the bone marrow has become recognized as a potential source of cells for non‐haematopoietic wound healing, in some instances demonstrating surprising plasticity in providing new epithelial cells. On the other hand, the contribution of bone marrow derived cells to fibrosis and blood vessel formation is more widely acknowledged. Tumour stroma has a vital role to play in determining cancer growth and spread, and there is a growing realization that the bone marrow has a significant input into this desmoplastic response. This review focuses on the contribution of bone marrow cells to tumour stroma, highlighting the bone marrow as a potential new portal through which to direct anti‐tumour therapies. Copyright © 2006 John Wiley & Sons, Ltd.