Premium
der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment
Author(s) -
Chim C S,
Ma S K
Publication year - 2005
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.750
Subject(s) - medicine , transformation (genetics) , chemistry , gene , biochemistry
We described a patient with ET that evolved into MF and then subsequently developed myeloblastic transformation. A novel derivative chromosome der(8)t(1;8) was identified in the AML phase. The only prior treatment had been hydroxyurea. We hypothesized that AML in this case resulted from a complex pre‐disposition by the natural progression of ET, prolonged use of HU, and the prior evolution into MF. The leukemogenic risk of HU is critically appraised. Copyright © 2005 John Wiley & Sons, Ltd.