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When epigenetics kills: MLL fusion proteins in leukemia
Author(s) -
Slany Robert K
Publication year - 2005
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.739
Subject(s) - epigenetics , leukemia , biology , fusion protein , fusion gene , lineage (genetic) , locus (genetics) , cancer research , gene , genetics , recombinant dna
Chromosomal aberrations that affect the MLL ( Mixed Lineage Leukemia ) gene at the locus 11q23 are associated with an aggressive subtype of leukemia. These alterations create MLL fusion derivatives with an active transforming potential. This review summarizes recent advances in our knowledge about normal and malignant MLL proteins with special emphasis on epigenetic processes affected by these molecules. Copyright © 2005 John Wiley & Sons, Ltd.