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Diagnosis of avascular necrosis of the femoral head in patients treated for lymphoma
Author(s) -
Ratcliffe Marcia A.,
Gilbert Fiona J.,
Dawson Audrey A.,
Bennett Bruce
Publication year - 1995
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900130303
Subject(s) - avascular necrosis , femoral head , medicine , lymphoma , head (geology) , surgery , geology , geomorphology
Avascular necrosis of bone (AVNB) is a well‐known but rare complication of chemotherapy for lymphoma with a reported incidence ranging from 1 to 10 per cent. Early diagnosis is essential for optimal therapeutic management. Using MRI, the most sensitive means of detecting the earlier stages of AVNB, 100 patients treated with standard chemotherapy for lymphoma were assessed. Fifteen were found to have changes of AVNB, 10 with early changes but five with advanced segmental collapse of the femoral head. None with AVNB had more than the standard course of corticosteroids. Almost a quarter of the study group complained of joint pain during and/or after their treatment, a third of whom were found to have AVNB; a strong indicator to screen all those with pain. However, 40 per cent of those with AVNB were asymptomatic. The clinical significance of the‘silent hip’ is yet to be elucidated.