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Oligonucleotides in the treatment of leukemia
Author(s) -
Bayever Eliel,
Iversen Patrick
Publication year - 1994
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900120103
Subject(s) - oligonucleotide , clinical trial , medicine , genetic enhancement , leukemia , bone marrow , function (biology) , intensive care medicine , computational biology , immunology , biology , gene , genetics
The use of synthetic oligonucleotides directed towards specific genes in the therapy of leukemias has evolved rapidly over the past 5 years to early clinical trials. Undoubtedly, use of these compounds for systemic therapy and bone marrow‘purging’ will escalate. Such trials will be models for the treatment of many other malignant diseases and, indeed, non‐malignant diseases which may be expected to respond to eradication of a specific gene function. We are currently at the threshold of a new era of therapy which holds the promise of totally transforming clinical medicine in the next decade.