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Protein kinase C isozyme expression in human leukemia–lymphoma cell lines—an immunocytochemical study
Author(s) -
Hojo Hiroshi,
Morimura Yutaka,
Abe Masafumi,
Tominaga Kunihiko,
Nozawa Yoshihiro,
Nakamura Naoya,
Ono Nobutaka,
Tasaki Kazuhiro,
Yamaguchi Yoshiko,
Suzuki Sayuri,
Wakasa Haruki
Publication year - 1992
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900100602
Subject(s) - protein kinase c , cell culture , isozyme , lymphoma , leukemia , microbiology and biotechnology , cell growth , biology , cell , cancer research , kinase , enzyme , biochemistry , immunology , genetics
There have been an increasing number of reports describing a pivotal role for phosphorylation in cellular responses for cell differentiation and proliferation. We examined an immunocytochemical expression of protein kinase C(PKC) isozymes (type I, II, and III) in 22 leukemia–lymphoma cell lines. Of these cell lines, 21 expressed type II PKC and 17 showed the co‐expression of both types II and III PKC in varying degree. The cell line without PKC activity showed far less [ 3 H]‐TdR uptake and no heterotransplantation in nude mice. Types II and III PKC appear to relate to cell proliferation in certain leukemia–lymphoma cell lines.