Premium
Acute myelogenous leukemia (AML) and diabetes insipidus (DI): Further association with monosomy 7
Author(s) -
Slater S. E.,
Maccallum P. K.,
Birjandi F.,
Gibbons B.,
Lister T. A.
Publication year - 1992
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900100313
Subject(s) - monosomy , diabetes insipidus , medicine , leukemia , complication , karyotype , pediatrics , pathology , chromosome , biology , genetics , gene
Abstract Diabetes insipidus (DI) is a rare complication of acute myelogenous leukemia (AML). Five of the six such cases described in the literature who had banded chromosomal studies performed had monosomy 7 and the sixth patient had del(7)(q22). A further case of AML complicated by DI in whom banded chromosomal studies revealed a complex karyotypic abnormality, including monosomy 7, is reported. The association between monosomy 7 and DI in AML appears specific but the reason for this association remains unclear.