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‘Aggressive’ low grade lymphocytic lymphomas can be identified by flow cytometric s‐phase determinations
Author(s) -
Lindh J.,
Jonsson H.,
Lenner P.,
Roos G.
Publication year - 1992
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900100307
Subject(s) - lymphoma , follicular phase , stage (stratigraphy) , working formulation , medicine , gastroenterology , follicular lymphoma , chronic lymphocytic leukemia , pathology , nuclear medicine , non hodgkin's lymphoma , biology , leukemia , paleontology
Forty‐five patients with low grade non‐Hodgkin's lymphomas were studied with respect to the fraction of S‐phase cells in fresh tumour material by flow cytometric analysis. Patients with stage I lymphomas were treated with radiotherapy, patients with stage II‐IV lymphomas with Prednimustine (Sterecyt R ). Patients with lymphocytic lymphomas of CLL type were only treated if they had symptoms. Median S‐phase fraction in the samples was 2‐0 per cent. A significantly shorter survival was found for patients with lymphocytic lymphomas with S‐phase fractions >2·0 per cent compared with cases showing lower S‐phase fractions. No significant difference in survival was found in the subgroups of immunocytic or follicular and follicular diffuse centroblastic/centrocytic lymphomas. In a Cox multivariate analysis, in which also age, constitutional symptoms, stage and morphology were included, the fraction of S‐phase cells was found to be a statistically significant, prognostic parameter for low grade lymphomas, mainly due to the result in the subgroup of lymphocytic lymphomas.