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Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)
Author(s) -
Nomura Abraham M. Y.,
Yanagihara Eugene T.,
Blattner William A.,
Ho Gloria Y. F.,
Inamasu Melvin S.,
Severson Richard K.,
Nakamura Jeffrey M.
Publication year - 1990
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900080308
Subject(s) - lymphoma , leukemia , medicine , adult t cell leukemia/lymphoma , antibody , etiology , t cell leukemia , virus , immunology , human t lymphotropic virus 1 , deltaretrovirus , virology , viral disease
In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.