Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL) | Zendy

Nomura Abraham M. Y. | Zendy; Yanagihara Eugene T. | Zendy; Blattner William A. | Zendy; Ho Gloria Y. F. | Zendy; Inamasu Melvin S. | Zendy; Severson Richard K. | Zendy; Nakamura Jeffrey M. | Zendy

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Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

Author(s) -

Nomura Abraham M. Y.,

Yanagihara Eugene T.,

Blattner William A.,

Ho Gloria Y. F.,

Inamasu Melvin S.,

Severson Richard K.,

Nakamura Jeffrey M.

Publication year - 1990

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2900080308

Subject(s) - lymphoma , leukemia , medicine , adult t cell leukemia/lymphoma , antibody , etiology , t cell leukemia , virus , immunology , human t lymphotropic virus 1 , deltaretrovirus , virology , viral disease

In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

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