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Normal B cell compartment in chronic lymphatic leukemia
Author(s) -
Pluta A.,
Górski A.,
Nowaczyk M.,
Modlińska M.
Publication year - 1990
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900080302
Subject(s) - cd5 , compartment (ship) , chronic lymphocytic leukemia , immunofluorescence , chronic lymphatic leukemia , b cell , antigen , pathology , lymphatic system , leukemia , medicine , biology , immunology , antibody , oceanography , geology
In contrast to normal B lymphocytes, CLL cells express CD5 antigen believed to be a T cell marker. We have assessed normal and malignant B cell compartments in CLL patients with the aid of two‐colour immunofluorescence techniques (CD5‐TRITC, DR‐FITC). No clear correlation was found between progression of disease and parameters studied. However, there was a tendency for a diminution of normal B cells in advanced stages of disease.