Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission | Zendy

Self S. E. | Zendy; Morgan S. | Zendy; Grush O. | Zendy; La Via M. F. | Zendy

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Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission

Author(s) -

Self S. E.,

Morgan S.,

Grush O.,

La Via M. F.

Publication year - 1990

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2900080204

Subject(s) - calla , medicine , flow cytometry , bone marrow , monoclonal antibody , lymphoblastic leukemia , antigen , acute lymphocytic leukemia , monoclonal , leukemia , immunology , population , pathology , antibody , environmental health

Bone marrows from 21 children with acute lymphoblastic leukemia in complete remission (CR) and off therapy for 14 months to 10 years were examined by flow cytometry with a panel of monoclonal antibodies. Significant percentages of cALLA + cells of low fluorescence intensity were present up to 9 years after CR. These results emphasize the need to interpret flow cytometry results in light of the findings that low intensity cALLA + cells represent a normal population of immature, non‐malignant lymphoid cells.

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