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Significance of common acute lymphoblastic leukemia antigen (cALLA) positive cells in bone marrow of children off therapy in complete remission
Author(s) -
Self S. E.,
Morgan S.,
Grush O.,
La Via M. F.
Publication year - 1990
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900080204
Subject(s) - calla , medicine , flow cytometry , bone marrow , monoclonal antibody , lymphoblastic leukemia , antigen , acute lymphocytic leukemia , monoclonal , leukemia , immunology , population , pathology , antibody , environmental health
Bone marrows from 21 children with acute lymphoblastic leukemia in complete remission (CR) and off therapy for 14 months to 10 years were examined by flow cytometry with a panel of monoclonal antibodies. Significant percentages of cALLA + cells of low fluorescence intensity were present up to 9 years after CR. These results emphasize the need to interpret flow cytometry results in light of the findings that low intensity cALLA + cells represent a normal population of immature, non‐malignant lymphoid cells.