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Primary intestinal lymphoma of Ki‐1 large cell anaplastic type with mesenteric lymph node and spleen involvement in a renal transplant recipient
Author(s) -
Audouin J.,
Le Tourneau A.,
Diebold J.,
Reynes M.,
Tabbah I.,
Bernadou A.
Publication year - 1989
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900070607
Subject(s) - medicine , spleen , lymphoma , lymph node , anaplastic large cell lymphoma , pathology , mesenteric lymph nodes , lymph , cancer research
A laparotomy performed for an occlusive syndrome, disclosed the presence of an ileal lymphoma in a renal graft recipient, 17 years after a first renal transplant. Mesenteric lymph node and spleen involvement were associated. The morphology of the large cells, the type of infiltration of the lymph node simulating metastatic carcinoma or malignant histiocytosis were highly suggestive of a new type of high grade malignancy lymphoma recently described which is called ‘large cell anaplastic ML’. The immunolabelling study confirmed this diagnosis, demonstrating the following phenotype CD4, CD25 (TAC), CD30 (Ki‐1), OKT 9 (transferrin receptor), EMA and HLA DR positivity. The tumour cells were negative for the other T, B and histiomono‐cytic markers. This case, of a large cell anaplastic Ki‐1 positive lymphoma, expressing CD4, in a renal graft recipient shows that high grade ML in such patients are not all of the B cell type.