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Philadelphia chromosome without breakpoint cluster region rearrangement in a case of Lennert's lymphoma of suppressor phenotype
Author(s) -
Terjanian Terenig,
Blick Mark B.,
Shtalrid Mordechai,
Manning John T.,
Trujillo Jose M.,
Cabanillas Fernando
Publication year - 1989
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900070302
Subject(s) - breakpoint , lymphoma , breakpoint cluster region , gene rearrangement , phenotype , biology , pathology , chromosome , cancer research , chronic myelogenous leukemia , chronic lymphocytic leukemia , leukemia , cytogenetics , philadelphia chromosome , chromosomal translocation , gene , medicine , genetics
A 60‐year‐old woman presented with diffuse lymphadenopathy. Diagnostic and staging work‐up showed that the patient had diffuse small cleaved cell lymphoma (diffuse poorly differentiated lymphocytic lymphoma) with associated histiocytes (lymphoepithelioid cell lymphoma) by the Kiel classification system. Immunohistologic staining showed a T suppressor cell tumour phenotype. Cytogenetic studies revealed the Philadelphia chromosome (Ph 1 ). On DNA studies, the breakpoint cluster region (BCR) gene was not rearranged suggesting that the Ph 1 involvement was not identical to that seen in chronic myelogenous leukemia (CML). This case is presented because of the rarity of Ph 1 in lymphoid malignancies, particularly in those of T‐cell origin, and because of its potentially adverse implications.