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Leucocyte common antigen in the differential diagnosis of Hodgkin's disease
Author(s) -
Strauchen James A.
Publication year - 1989
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900070206
Subject(s) - medicine , disease , immunology , differential diagnosis , differential (mechanical device) , antigen , pathology , physics , thermodynamics
The utility of immunohistochemical staining for leukocyte common antigen (LCA) in the differential diagnosis of Hodgkin's disease was studied in a series of 42 cases of Hodgkin's and non‐Hodgkin's lymphoma and compared with Leu M‐1, a proposed marker for Reed‐Sternberg cells. LCA staining of neoplastic cells was absent in 23 of 24 cases of Hodgkin's disease but present in 16 of 18 cases of non‐Hodgkin's lymphoma including eight of 10 cases with pleomorphic Reed‐Sternberg‐like cells. Leu M‐1, in contrast was present in 14 of 24 cases of Hodgkin's disease, but also in five of 18 cases of non‐Hodgkin's lymphoma including five of 10 cases with pleomorphic Reed‐Sternberg‐like cells. Immunohistochemical staining for LCA appears useful in the differential diagnosis of Hodgkin's disease and appears to be a better discriminant than Leu M‐1.