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Severe lung toxicity with a weekly low dose chemotherapy regimen in patients with non‐Hodgkin's lymphoma
Author(s) -
Quigley M.,
Brada M.,
Heron C.,
Horwich A.
Publication year - 1988
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900060407
Subject(s) - medicine , bleomycin , cyclophosphamide , vincristine , mitoxantrone , pneumonitis , chemotherapy , prednisolone , gastroenterology , lymphoma , pulmonary toxicity , non hodgkin's lymphoma , regimen , combination chemotherapy , toxicity , lung
Nineteen patients in poor prognostic subgroups of aggressive non‐Hodgkin's lymphoma (NHL) were treated with weekly chemotherapy consisting of low dose mitoxantrone and cyclophosphamide alternating with bleomycin and vincristine together with continuous oral prednisolone. Six patients developed pneumonitis which was severe in five patients. This occurred at total bleomycin doses of < 50 U/m 2 and cyclophosphamide < 1875 mg/m 2 . The 31 per cent incidence of pneumonitis following low dose bleomycin suggests an increased susceptibility to drug‐induced pulmonary damage in non‐Hodgkin's lymphoma.