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Blood lymphocyte characteristics as predictors of prognosis in chronic lymphocytic leukemia of B‐cell type
Author(s) -
Kimby E.,
Mellstedt H.,
Nilsson B.,
Björkholm M.,
Holm G.,
Lindemalm C.,
Tribukait B.
Publication year - 1988
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900060108
Subject(s) - clone (java method) , chronic lymphocytic leukemia , lymphocyte , immunology , medicine , isotype , leukemia , multivariate analysis , blood cell , antibody , oncology , biology , monoclonal antibody , dna , genetics
The prognostic information of blood lymphocyte characteristics and clinical findings was assessed in 62 patients with chronic lymphocytic leukemia of B cell type. Bivariate and multivariate survival analyses were performed using age, Rai stage, surface membrane immunoglobulin (smIg) isotype pattern of the leukemic clone, total lymphocyte counts, numbers of proliferating lymphocytes and T cell subpopulations. Rai stages III and IV, high numbers of blood lymphocytes in S‐phase (S + ) and smμ isotype were found to be partly independent factors predicting short therapy‐free survival. Patients with a smμ + leukemic cell clone had a shorter therapy‐free and total survival compared to those with smμ + /δ + and smδ + leukemic cells. Moreoever, patients with high numbers of blood S + lymphocytes had a shorter therapy‐free and total survival compared to those with few S + cells. These prognostic variables were valid also in patients with a low tumour burden (Rai stages 0, I and II) and may thus be of clinical importance as a guideline for therapeutic intervention.