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Interferon induces proliferation in leukemic and normal B‐cell subsets
Author(s) -
Robért KarlHenrik,
Einhorn Stefan,
Östlund Leif,
Juliusson Gunnar,
Biberfeld Peter
Publication year - 1986
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900040203
Subject(s) - immunology , spleen , interferon , leukemia , chronic lymphocytic leukemia , hairy cell leukemia , lymphocyte , cell , b cell , thymidine , biology , cell growth , in vitro , medicine , antibody , biochemistry , genetics
3 H‐thymidine incorporation following stimulation with interferon (IFN) in vitro was investigated in cell cultures from peripheral blood of patients with chronic lymphocytic leukemia (CLL), spleens from necro‐kidney transplants and healthy blood donors. It was demonstrated, that IFN can induce a proliferative response in some normal as well as leukemic B lymphocyte subsets. The responses were not T‐cell dependant. The results indicate, that B‐cell subsets that proliferate in the presence of IFN, are present in higher proportions in spleen than in peripheral blood, and that they constitute a portion of the leukemic blood lymphocyte pool in some patients with CLL We have previously demonstrated, that IFN induces varying degrees of transformation and differentiation in blood lymphocytes from a majority of CLL patients. The functional characteristics of different B‐cell subsets, and their heterogenous distribution in leukemia, may be important for the results of IFN treatment in various malignant B‐cell disorders.