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Human t‐cell leukemia virus: Causative roles in development of adult t‐cell leukemia and provirus integration into leukemic cell DNA
Author(s) -
Yoshida M.,
Seiki M.
Publication year - 1986
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900040104
Subject(s) - provirus , leukemia , virology , t cell leukemia , virus , cell , biology , human t lymphotropic virus 1 , lymphoma , medicine , immunology , genome , gene , genetics
Human T‐cell leukemia virus (HTLV) was isolated from a cutaneous T‐cell lymphoma patient by Gallo and his colleagues (Poiesz et al. , 1980) and adult T‐cell leukemia virus (ATLV) was isolated from patients with adult T‐cell leukemia (ATL) in Japan (Yoshida et al. , 1982). Originally, these two viral isolates were thought to be different since they were isolated from apparently different tumors. However, we have shown that HTLV in the Caribbean and ATLV in Japan are the same virus (Watanabe et al. , 1983, 1984) and the patient from which HTLV was isolated was identified as an atypical case of ATL (Bunn et al. , 1983).