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A report on a prospective trial of no initial therapy in patients with asymptomatic favourable prognosis non‐Hodgkin's lymphoma
Author(s) -
Mead G. M.,
Macbeth F. R.,
Ryall R. D. H.,
Williams C. J.,
Whitehouse J. M. A.
Publication year - 1984
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900020207
Subject(s) - medicine , asymptomatic , prospective cohort study , lymphoma , surgery , chemotherapy , stage (stratigraphy) , disease , randomized controlled trial , paleontology , biology
Abstract Thirty‐one (58 per cent) of a group of fifty‐three unselected patients with stage II–IV favourable prognosis non‐Hodgkin's lymphoma were regarded as being eligible for a prospective study of no initial therapy. Seventeen of these patients (55 per cent) have required no treatment for periods from 6 + −47 + months, (median 18 months) and fourteen patients have been treated with chemotherapy for progressive disease after a period varying from 3–40 months (median 9·5 months). Selected asymptomatic patients with non‐bulky disease may be suitable for no initial therapy. Randomized prospective trials will be needed to test whether survival is affected by delaying therapy.