Interactions between radioresistant T Cells from plasmacytoma‐bearing mice and radiosensitive T Cells from normal mice leading to suppression | Zendy

Muul Linda Mesler | Zendy; Roberson Bob S. | Zendy; Broder Samuel | Zendy

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Interactions between radioresistant T Cells from plasmacytoma‐bearing mice and radiosensitive T Cells from normal mice leading to suppression

Author(s) -

Muul Linda Mesler,

Roberson Bob S.,

Broder Samuel

Publication year - 1983

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2900010110

Subject(s) - radioresistance , splenocyte , population , plasmacytoma , suppressor , microbiology and biotechnology , biology , immunology , t cell , spleen , cell , cancer research , cell culture , medicine , immune system , biochemistry , multiple myeloma , genetics , environmental health , gene

Spleens from BALB/c mice bearing the plasmacytoma SPQC 11 contain a population of T cells capable of suppressing the production of antibodies when cultured with normal BALB/c splenocytes, but not with splenocytes from nude BALB/c mice. Inhibition was characteristically the most effective at low suppressor cell numbers using unirradiated T cells. Maximum suppression occurred when a radiosensitive population of T cells from normal mice interacted with a population of radioresistant T cells from plasmacytoma‐bearing animals. Accurate characterization of the suppressor T cell activity required testing over a wide range of suppressor/indicator cell ratios. Suppressor activity was eliminated by treatment with anti‐Thy 1.2 plus complement, was radioresistant and present over a full range of doses when irradiated cells were used.

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