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Interactions between radioresistant T Cells from plasmacytoma‐bearing mice and radiosensitive T Cells from normal mice leading to suppression
Author(s) -
Muul Linda Mesler,
Roberson Bob S.,
Broder Samuel
Publication year - 1983
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2900010110
Subject(s) - radioresistance , splenocyte , population , plasmacytoma , suppressor , microbiology and biotechnology , biology , immunology , t cell , spleen , cell , cancer research , cell culture , medicine , immune system , biochemistry , multiple myeloma , genetics , environmental health , gene
Spleens from BALB/c mice bearing the plasmacytoma SPQC 11 contain a population of T cells capable of suppressing the production of antibodies when cultured with normal BALB/c splenocytes, but not with splenocytes from nude BALB/c mice. Inhibition was characteristically the most effective at low suppressor cell numbers using unirradiated T cells. Maximum suppression occurred when a radiosensitive population of T cells from normal mice interacted with a population of radioresistant T cells from plasmacytoma‐bearing animals. Accurate characterization of the suppressor T cell activity required testing over a wide range of suppressor/indicator cell ratios. Suppressor activity was eliminated by treatment with anti‐Thy 1.2 plus complement, was radioresistant and present over a full range of doses when irradiated cells were used.