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Personalized medicine for Hodgkin lymphoma: Mitigating toxicity while preserving cure
Author(s) -
Longley Jemma,
Johnson Peter W. M.
Publication year - 2021
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2856
Subject(s) - brentuximab vedotin , medicine , oncology , clinical trial , lymphoma , hodgkin lymphoma , intensive care medicine , quality of life (healthcare) , personalized medicine , risk stratification , bioinformatics , nursing , biology
The treatment of classical Hodgkin lymphoma in young patients is one of the success stories of modern medicine. The use of risk‐ and response‐adapted approaches to guide treatment decisions has led to impressive cure rates while reducing the long‐term toxicity associated with more intensive therapies. Tissue biomarkers have not yet proven more effective than clinical characteristics for risk stratification of patients at presentation, but functional imaging features such as metabolic tumor volume may be used to predict response, if early observations can be validated. The success of treatment in younger patients has unfortunately not been mirrored in those over 60, where complex decision‐making is often required, with a paucity of data from clinical trials. The use of PD1 blocking antibodies and brentuximab vedotin in this cohort, either alone or in combination with chemotherapy, may provide attractive options. The incorporation of frailty assessment, quality‐of‐life outcomes, and specialist geriatric input is also important to ensure the best outcomes for this diverse group.