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In vitro maturation is a viable option for urgent fertility preservation in young women with hematological conditions
Author(s) -
Sonigo Charlotte,
Bajeux Jeanne,
Boubaya Marouane,
Eustache Florence,
Sifer Christophe,
Lévy Vincent,
Grynberg Michaël,
Sermondade Nathalie
Publication year - 2020
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2724
Subject(s) - fertility preservation , context (archaeology) , fertility , medicine , in vitro maturation , ovarian tissue cryopreservation , cryopreservation , in vitro fertilisation , chemotherapy , gynecology , oocyte , surgery , biology , population , pregnancy , embryo , paleontology , genetics , environmental health , microbiology and biotechnology
Fertility preservation embraces different techniques developed to improve young women chances of becoming mothers after healing. Among them, in vitro maturation (IVM) procedure is based on oocyte retrieval without any gonadotropin treatment, feasible under locoregional or local anesthesia, with very low operative complications. The present retrospective analysis of a preliminary case series of 25 women diagnosed with Hodgkin or non‐Hodgkin lymphoma aims to evaluate the feasibility of IVM for urgent fertility preservation purposes in hematological context. A median of five mature oocytes was cryopreserved after one cycle of IVM, performed without delaying the start of the chemotherapy (median delay from histological diagnosis to start of the chemotherapy 17.5 days). No association was found between lymphomas' characteristics and the number of recovered or frozen oocytes. Although experimental, this technique could be relevant when fertility preservation has to be performed within a short time frame and without additional surgery nor any risk of malignant cells reintroduction.