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Primary central nervous system lymphoma: A curable disease
Author(s) -
Batchelor Tracy T.
Publication year - 2019
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2598
Subject(s) - lymphoma , leptomeninges , medicine , primary central nervous system lymphoma , chemotherapy , methotrexate , autologous stem cell transplantation , central nervous system , pathology , transplantation , cancer research , oncology , immunology
Primary central nervous system lymphoma is a rare subtype of non‐Hodgkin lymphoma that is confined to the brain, leptomeninges, or the eye and is associated with a relatively poor prognosis compared to other extranodal diffuse large B‐cell lymphomas. However, methotrexate‐based induction chemotherapy followed by consolidative chemotherapy or high‐dose therapy and autologous stem cell transplantation is associated with improved survival and reduced neurotoxicity. Aberrant activation of B‐cell receptor signaling and activation of nuclear factor kappa beta is a frequent genetic alteration and offers opportunities for targeted therapies in this lymphoma subtype.