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Differential expression of estrogen receptor–α on follicular dendritic cells from patients with grade 1‐2 and grade 3 follicular lymphoma
Author(s) -
Ohe Rintaro,
Meng HongXue,
Ye Aung Naing,
Yamada Akane,
Kabasawa Takanobu,
Utsunomiya Aya,
Tamazawa Nobuyuki,
Tamura Yuka,
Kitaoka Takumi,
Hashimoto Toshio,
Shibata Kenichi,
Toubai Tomomi,
Kimura Wataru,
Ishizawa Kenichi,
Yamakawa Mitsunori
Publication year - 2019
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2577
Subject(s) - cd23 , follicular dendritic cells , follicular lymphoma , follicular phase , lymph , germinal center , estrogen receptor , medicine , cancer research , axillary lymph nodes , pathology , lymphoma , biology , b cell , breast cancer , immunology , cancer , t cell , antibody , antigen presenting cell , immunoglobulin e , immune system
Hormone therapy has been used for patients with estrogen receptor alpha (ERα)–positive breast cancers. Recently, some studies reported the expression of ERα on neoplastic cells from B‐cell lymphomas. However, there has been only one report of ERα expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). The objective of this study was to investigate the frequency of ERα expression on FDCs in nonneoplastic reactive lymphoid tissues and to compare the frequency of ERα expression on FDCs in the axillary lymph nodes between patients with and without antiestrogen therapy and among patients with grades 1‐3 of FL. Reverse transcription–polymerase chain reaction was performed to detect ERα mRNA in FL. In nonneoplastic germinal centers (GCs) from patients with tonsillitis or reactive lymphadenitis, ERα was expressed in the light zone. ERα‐positive cells strongly correlated with the width of GCs ( r s = 0.81, P < 0.01) and the CD21‐positive ( r s = 0.69, P < 0.01) and CD23‐positive ( r s = 0.83, P < 0.01) FDC meshwork. The axillary lymph nodes had fewer ERα‐positive cells, smaller GCs, and a looser CD21‐ and CD23‐positive FDC meshwork with hormone therapy than without hormone therapy ( P < 0.01). Neoplastic follicles of G1‐2 FL had more ERα‐positive cells and a larger CD23 + FDC meshwork than those of G3 FL ( P < 0.01). ERα mRNA was detected in both G1‐2 FL and G3 FL by reverse transcription–polymerase chain reaction. In conclusion, these results suggested that antiestrogen hormone therapy may decrease the number of ERα‐positive FDCs and that the responses mediated by the estrogen‐ERα interaction on FDCs may differ between G1‐2 FL and G3 FL.