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Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome
Author(s) -
Autore Francesco,
Innocenti Idanna,
Luigetti Marco,
Piccirillo Nicola,
Sora Federica,
Chiusolo Patrizia,
Sica Simona,
Bacigalupo Andrea,
Laurenti Luca
Publication year - 2018
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2478
Subject(s) - poems syndrome , lenalidomide , autologous stem cell transplantation , medicine , stem cell , transplantation , peripheral blood stem cells , oncology , chemotherapy , surgery , multiple myeloma , hematopoietic stem cell transplantation , biology , polyneuropathy , genetics
POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization.