Angiopoietin‐2 acts as a survival factor for chronic lymphocytic leukemia  B  cells throughout  T ie‐2 receptor engagement | Zendy

Maffei Rossana | Zendy; Fiorcari Stefania | Zendy; Martinelli Silvia | Zendy; Guarnotta Carla | Zendy; Benatti Stefania | Zendy; Belmonte Beatrice | Zendy; Potenza Leonardo | Zendy; Luppi Mario | Zendy; Marasca Roberto | Zendy

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Angiopoietin‐2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout T ie‐2 receptor engagement

Author(s) -

Maffei Rossana,

Fiorcari Stefania,

Martinelli Silvia,

Guarnotta Carla,

Benatti Stefania,

Belmonte Beatrice,

Potenza Leonardo,

Luppi Mario,

Marasca Roberto

Publication year - 2018

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2448

Subject(s) - dapi , chronic lymphocytic leukemia , stain , receptor , staining , cancer research , microbiology and biotechnology , leukemia , biology , medicine , immunology , chemistry , pathology

we demonstrated that: (i) CLL cells expressed Tie-2 receptor both in peripheral blood and in lymph nodes; (ii) Ang2 may interact with Tie-2 in CLL mediating a survival signal throughout PI3K-AKT signalling, and (iii) the interruption of Ang2/Tie-2 signalling may be effective in CLL

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