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Angiopoietin‐2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout T ie‐2 receptor engagement
Author(s) -
Maffei Rossana,
Fiorcari Stefania,
Martinelli Silvia,
Guarnotta Carla,
Benatti Stefania,
Belmonte Beatrice,
Potenza Leonardo,
Luppi Mario,
Marasca Roberto
Publication year - 2018
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2448
Subject(s) - dapi , chronic lymphocytic leukemia , stain , receptor , staining , cancer research , microbiology and biotechnology , leukemia , biology , medicine , immunology , chemistry , pathology
we demonstrated that: (i) CLL cells expressed Tie-2 receptor both in peripheral blood and in lymph nodes; (ii) Ang2 may interact with Tie-2 in CLL mediating a survival signal throughout PI3K-AKT signalling, and (iii) the interruption of Ang2/Tie-2 signalling may be effective in CLL