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ROLE OF UP‐FRONT AUTOLOGOUS STEM CELL TRANSPLANTATION IN PERIPHERAL T‐CELL LYMPHOMAS: a PROPENSITY SCORE MATCHING ANALYSIS OF PATIENTS FROM LYSA CENTERS
Author(s) -
Fossard G.,
Broussais F.,
Coelho I.,
Bailly S.,
NicolasVirelizier E.,
Toussaint E.,
Lancesseur C.,
Lebras F.,
Willems E.,
Tcherog E.,
Delarue R.,
Gressin R.,
Chauchet A.,
Gyan E.,
Cartron G.,
Bonnet C.,
Haioun C.,
Damaj G.,
Gaulard P.,
Fornecker L.,
Ghesquieres H.,
Tournilhac O.,
Gomes Da Silva M.,
Bouabdallah R.,
Salles G.,
Bachy E.
Publication year - 2017
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2437_64
Subject(s) - medicine , propensity score matching , hazard ratio , oncology , peripheral t cell lymphoma , autologous stem cell transplantation , proportional hazards model , cohort , confidence interval , transplantation , hematopoietic stem cell transplantation , confounding , surgery , immunology , t cell , immune system
A = 57.1% and Arm B = 43.2% (p = 0.24). Overall rates of grade ≥ 3 toxicity were similar between arms, 67.0% vs 73.0% (p = 0.64); however more ≥3 grade neutropenia (p = 0.036) and febrile neutropenia (p = 0.03) were seen in Arm A; while Arm B had more ≥3 grade thrombocytopenia (p = 0.03). At a median follow‐up of 18.1 months, there was no difference in 2‐yr overall survival (Arm A = 53.1%, Arm B = 64.7%, p = 0.56) or progression‐free survival (Arm A = 36.0%, Arm B = 39.0%, p = 0.81). Conclusion: The EOT CR/CRu rate in Arm B (GEM‐P) was not superior to Arm A (CHOP), and Arm B was associated with higher rates of study withdrawal. CHOP remains the reference regimen in PTCL.