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Non‐Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand
Author(s) -
Intragumtornchai Tanin,
Bunworasate Udomsak,
Wudhikarn Kitsada,
Lekhakula Arnuparp,
Julamanee Jakrawadi,
Chansung Kanchana,
Sirijerachai Chittima,
Norasetthada Lalita,
Nawarawong Weerasak,
Khuhapinant Archrob,
Siritanaratanakul Noppadol,
Numbenjapon Tontanai,
Prayongratana Kannadit,
Chuncharunee Suporn,
Niparuck Pimjai,
Suwanban Tawatchai,
Kanitsap gluk,
Wongkhantee Somchai,
Pornvipavee Rutchanid,
Wong Peerapon,
Makruasi Nisa,
Wannakrairot Pongsak,
Assanasen Thamathorn,
Sukpanichnant Sanya,
Boonsakan Paisarn,
Kanoksil Wasana,
Yain Charin,
Kayasut Kanita,
Mitranun Winyu,
Warnnissorn Naree
Publication year - 2018
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2392
Subject(s) - lymphoma , medicine , histopathology , follicular lymphoma , mucosa associated lymphoid tissue , malt lymphoma , pathology , epidemiology , t cell lymphoma
Systemic reports on the descriptive epidemiology of non‐Hodgkin lymphoma (NHL) from Southeast Asia are scarce. A nationwide multi‐institutional registry was conducted to compare the histopathology, clinical features, and survival of Thai adult patients with NHL using large registries, especially those from Far East Asia (FEA). Using a web‐based registry system, 13 major medical centers from the 4 geographic regions of Thailand prospectively collected, from 2007 to 2014, the diagnostic pathology, according to the World Health Organization classification, 2008, clinical features and survival of 4056 patients who were newly diagnosed with NHL. The median age of the patients was 56 years (range, 16‐99 years). The male‐to‐female ratio was 1.3:1. From the total of 4056 patients, T/NK‐cell lymphoma (TNKCL) accounted for 12.6% of cases, and 5.1% had human immunodeficiency virus–associated lymphoma. The four leading histological subtypes were diffuse large B‐cell lymphoma, not otherwise specified (58.1%); follicular lymphoma (5.6%); extranodal mucosa‐associated lymphoid tissue lymphoma (5.2%); and peripheral T‐cell lymphoma, not otherwise specified (4.0%). With a median follow‐up duration of 46.1 months, the median overall survival of B‐cell NHL was significantly longer than that of patients with TNKCL (76.5 vs 28.8 months, P = .0001). Compared to FEA, the Thai registry had an approximately one‐half lower relative frequency of TNKCL; the prevalence of extranodal mucosa‐associated lymphoid tissue lymphoma was much lower than in Korea, and the frequency of extranodal TNKCL, nasal type, was strikingly low compared to China. It is concluded that while the median age of Thai patients with NHL was approximately a decade younger than for Caucasians, the long‐term survival rates for most histological subtypes were comparable. While the histological distribution generally complied with the characteristic Asian features, some differences from FEA were observed.