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The effect of microenvironmental factors on the development of myeloma cells
Author(s) -
Márk Ágnes,
Varga Gergely,
Timár Botond,
Kriston Csilla,
Szabó Orsolya,
Deák Linda,
Matolcsy András,
Barna Gábor
Publication year - 2017
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2354
Subject(s) - stromal cell , bone marrow , cd20 , multiple myeloma , clone (java method) , cancer research , biology , antigen , immunology , medicine , pathology , dna , genetics
Multiple myeloma (MM) is a clonal B‐cell malignancy characterized by the accumulation of monoclonal plasma cells (PCs) in the bone marrow and other tissues. Although there are several new therapies, MM remains fatal. The interaction between MM cells and the bone marrow microenvironment promotes drug resistance and cancer cells survival. In our present work, we compared the antigen expression pattern of normal and pathological PCs and investigated the possible connections between various surface receptors, adhesion molecules, and recurrent genetic aberrations. We showed that the expression of CD29, CD27, and CD81 is lower in MM cells than in normal PCs. We found correlation of chromosome 11 hyperdiploidity and the decrease of CD27 expression. We demonstrated that MM cells with CD20 positivity also have CD28 expression. Multiple myeloma patients with active CD29 showed better response to treatment. Our results suggest that these changes may result in an alteration of the interaction between stromal cell and MM cell facilitating cell survival and the development of a more aggressive and resistant phenotype.