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Trichosporon : another yeast‐like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy
Author(s) -
AlbyLaurent Fanny,
Dollfus Catherine,
AitOufella Hafid,
Rambaud Jerome,
Legrand Ollivier,
Tabone MarieDominique,
Hennequin Christophe
Publication year - 2017
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2309
Subject(s) - fungemia , trichosporon , medicine , malignancy , neutropenia , immune system , immunology , immune dysfunction , hematological malignancy , pancytopenia , chemotherapy , pathology , mycosis , bone marrow , biology , genetics , yeast
Trichosporon has recently emerged as a life‐threatening opportunistic fungal pathogen, notably in patients with hematological malignancy. Fungemia, sometimes associated with cutaneous lesions and/or pneumonitis, is the major clinical form. Here, we report two cases of patients suffering from acute leukaemia who developed hepatic and/or splenic lesions apart from Trichosporon positive blood cultures. The appearance of hepatic and splenic lesions following the recovery from neutropenia is highly suggestive of a chronic disseminated infection, now considered as an immune reconstitution inflammatory syndrome. Treatment with corticosteroid therapy led to clinical improvement in both cases. Copyright © 2016 John Wiley & Sons, Ltd.