Trichosporon : another yeast‐like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy | Zendy

AlbyLaurent Fanny | Zendy; Dollfus Catherine | Zendy; AitOufella Hafid | Zendy; Rambaud Jerome | Zendy; Legrand Ollivier | Zendy; Tabone MarieDominique | Zendy; Hennequin Christophe | Zendy

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Trichosporon : another yeast‐like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy

Author(s) -

AlbyLaurent Fanny,

Dollfus Catherine,

AitOufella Hafid,

Rambaud Jerome,

Legrand Ollivier,

Tabone MarieDominique,

Hennequin Christophe

Publication year - 2017

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2309

Subject(s) - fungemia , trichosporon , medicine , malignancy , neutropenia , immune system , immunology , immune dysfunction , hematological malignancy , pancytopenia , chemotherapy , pathology , mycosis , bone marrow , biology , genetics , yeast

Trichosporon has recently emerged as a life‐threatening opportunistic fungal pathogen, notably in patients with hematological malignancy. Fungemia, sometimes associated with cutaneous lesions and/or pneumonitis, is the major clinical form. Here, we report two cases of patients suffering from acute leukaemia who developed hepatic and/or splenic lesions apart from Trichosporon positive blood cultures. The appearance of hepatic and splenic lesions following the recovery from neutropenia is highly suggestive of a chronic disseminated infection, now considered as an immune reconstitution inflammatory syndrome. Treatment with corticosteroid therapy led to clinical improvement in both cases. Copyright © 2016 John Wiley & Sons, Ltd.

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