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Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis
Author(s) -
Zhu Jingcheng,
Si Mengya,
Li Yazhen,
Chen Huanzhu,
Fan Zhicheng,
Xie Qingdong,
Jiao Xiaoyang
Publication year - 2017
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2289
Subject(s) - blood–brain barrier , tight junction , central nervous system , brain metastasis , medicine , neuroscience , metastasis , biology , microbiology and biotechnology , cancer
The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher ( p < 0.05), but CSF ZO‐1 levels were not significantly higher in the CNS leukaemia (CNSL) compared to the non‐CNSL. The CNSL patients also had a lower CLDN5/ZO1 ratio in both serum and CSF than in non‐CNSL patients ( p < 0.05). The TJ index was negatively associated with WBC CSF , ALB CSF and BBB values in leukaemia patients. Among all of the parameters studied, CLDN5 CSF had the highest specificity in discriminating between CNSL and non‐CNSL patients. Therefore, analysing serum and CSF levels of CLDN5, OCLN and the CLDN5/ZO1 ratio is valuable in evaluating the potential of leukaemia CNS metastasis. Copyright © 2016 John Wiley & Sons, Ltd.