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Oxidative status in treatment‐naïve essential thrombocythemia: a pilot study in a single center
Author(s) -
Iurlo Alessandra,
De Giuseppe Rachele,
Sciumè Mariarita,
Cattaneo Daniele,
Fermo Elisa,
De Vita Claudia,
Consonni Dario,
Maiavacca Rita,
Bamonti Fabrizia,
Gianelli Umberto,
Cortelezzi Agostino
Publication year - 2017
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2264
Subject(s) - glutathione , oxidative stress , reactive oxygen species , essential thrombocythemia , medicine , pathogenesis , dyslipidemia , lipid peroxidation , endocrinology , pharmacology , chemistry , gastroenterology , biochemistry , platelet , diabetes mellitus , enzyme
Oxidative stress (OS), due to pro‐oxidant species [reactive oxygen species (ROS)] excess not counterbalanced by endogenous antioxidant molecules [e.g., reduced glutathione (GSH)], is involved in the pathogenesis of human cancers, but few data are available on essential thrombocythemia (ET). This study aims to investigate OS in ET off‐therapy patients. Thirty ET treatment‐naïve patients were compared with 26 age‐matched and gender‐matched controls. Serum ROS, urinary 8‐hydroxydeoxyguanosine, full blood GSH levels, and reduced/oxidized GSH ratio (GSH/GSSG) were measured. Data were adjusted for gender, age, JAK2 mutational status, smoking, dyslipidemia, or hypercholesterolemia requiring drug therapy, antiplatelet therapy, treatment with acetylsalicylic acid, high‐sensitive C‐reactive protein levels, and absolute monocyte count. ROS and GSH levels were increased in both patients and controls. Patients showed increased GSSG ( p = 0.05), reduced GSH/GSSG ratio ( p = 0.08), and similar 8‐hydroxydeoxyguanosine levels when compared with controls. No differences in OS parameters were found between JAK2 ‐positive and JAK2 ‐negative patients. Confounding factors did not modify the results. Our study suggests an OS condition in a cohort of treatment‐naïve ET patients, not associated with JAK2 mutational status or with chronic inflammation situation. GSH/GSSG ratio, altered in ET patients because of increased GSSG levels, showed the presence of higher GSH levels in ET than controls as a possible compensatory mechanism of an excess of pro‐oxidant production. Copyright © 2015 John Wiley & Sons, Ltd.