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Detection rate of fluorine‐18‐fluorodeoxyglucose positron emission tomography in patients with marginal zone lymphoma of MALT type: a meta‐analysis
Author(s) -
Treglia Giorgio,
Zucca Emanuele,
Sadeghi Ramin,
Cavalli Franco,
Giovanella Luca,
Ceriani Luca
Publication year - 2015
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2152
Subject(s) - medicine , malt lymphoma , positron emission tomography , lymphoma , nuclear medicine , mucosa associated lymphoid tissue , fluorodeoxyglucose , positron emission tomography computed tomography , confidence interval , pet ct , radiology
The aim of this article is to meta‐analyse published data about the detection rate (DR) of fluorine‐18‐fluorodeoxyglucose ( 18 F‐FDG) positron emission tomography (PET) and PET/computed tomography (CT) in the evaluation of patients with marginal zone lymphoma of the mucosa‐associated lymphoid tissue (MALT). A comprehensive literature search of studies published through February 2014 was performed. Pooled DR of 18 F‐FDG PET or PET/CT including 95% confidence intervals (95% CI) was calculated on a per‐patient‐based analysis. Twenty studies including 376 patients with MALT lymphoma were selected. The pooled DR of 18 F‐FDG PET or PET/CT was 71% (95% CI: 61–80%). A significant difference between the DR of PET/CT (69%; 95% CI: 61–80%) and that of PET alone (73%; 95% CI: 60–84%) was not demonstrated. A better DR of 18 F‐FDG PET or PET/CT in bronchial (94%; 95% CI: 85–99%) and head‐and‐neck (90%; 95% CI: 78–98%) MALT lymphomas compared with gastric (62%; 95% CI: 46–77%) and ocular (49%; 95% CI: 36–63%) MALT lymphomas was found. This meta‐analysis demonstrates that MALT lymphoma is an 18 F‐FDG‐avid tumour in most of the cases, suggesting a potential clinical role of 18 F‐FDG PET or PET/CT in the initial evaluation of these patients. In particular, the DR of 18 F‐FDG PET or PET/CT is related to the primary site of the MALT lymphoma. Copyright © 2014 John Wiley & Sons, Ltd.