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Piceatannol exhibits selective toxicity to multiple myeloma cells and influences the Wnt/ beta‐catenin pathway
Author(s) -
Schmeel Frederic Carsten,
Schmeel Leonard Christopher,
Kim Young,
SchmidtWolf Ingo G. H.
Publication year - 2014
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2122
Subject(s) - multiple myeloma , wnt signaling pathway , toxicity , piceatannol , cancer research , medicine , chemistry , oncology , pharmacology , biochemistry , gene , resveratrol
Aberrant activation of Wnt/β‐catenin signaling promotes development and progression of various malignant neoplasms. Recent studies observed that the Wnt pathway is constitutively active in myeloma cells and promotes an exaggerated proliferation. Thus, the Wnt signaling pathway might be an attractive therapeutic target for multiple myeloma. In this study, we identified piceatannol as an inhibitor of the Wnt/β‐catenin pathway and as a potent inducer of apoptosis in myeloma cells. Interestingly, healthy cells remained mainly unaffected. These results reveal a significant selective induction of apoptosis by piceatannol and suggest a significant in vivo effect against multiple myeloma. Copyright © 2014 John Wiley & Sons, Ltd.