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Influence of ethnicity and improved outcome of acute myeloid leukaemia: two decades of follow‐up of Israeli patient cohort
Author(s) -
Goldschmidt Neta,
Cohen Sara B.,
Gatt Moshe E.,
Safrai Myriam,
Rund Deborah
Publication year - 2014
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2092
Subject(s) - medicine , cohort , myeloid leukaemia , overall survival , oncology , bone marrow , myeloid , ethnic group , myeloid leukemia , transplantation , cytogenetics , disease , biochemistry , chemistry , sociology , anthropology , chromosome , gene
Acute myeloid leukaemia is a disease with unfavourable prognosis. The significance of various prognostic parameters is not fully understood. We studied 293 patients to examine the influence of ethnicity and molecular markers. The median survival for all patients was correlated with age, white blood cell count and karyotype, and marginally with FLT3 internal tandem duplication. Arab patients were younger than Jewish patients; however, their survival was poorer albeit being treated with the same protocols and having more favourable cytogenetics. Survival rates improved over time but only for patients undergoing allogeneic bone marrow transplantation (alloBMT). We conclude that in our young patient cohort, recent improvement in survival is attributed to alloBMT therapy and that ethnicity affected treatment outcome. Copyright © 2013 John Wiley & Sons, Ltd.