Hemophagocytic lymphohistiocytosis after allogeneic bone marrow transplantation during chronic norovirus infection | Zendy

Salvador Christina | Zendy; Meister Bernhard | Zendy; Larcher Heike | Zendy; Crazzolara Roman | Zendy; Kropshofer Gabriele | Zendy

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Hemophagocytic lymphohistiocytosis after allogeneic bone marrow transplantation during chronic norovirus infection

Author(s) -

Salvador Christina,

Meister Bernhard,

Larcher Heike,

Crazzolara Roman,

Kropshofer Gabriele

Publication year - 2014

Publication title -

hematological oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 44

eISSN - 1099-1069

pISSN - 0278-0232

DOI - 10.1002/hon.2052

Subject(s) - medicine , hemophagocytic lymphohistiocytosis , immunology , cytomegalovirus , malignancy , macrophage activation syndrome , bone marrow , bone marrow transplantation , transplantation , norovirus , virus , disease , virology , herpesviridae , viral disease , pathology , arthritis

Hemophagocytic lymphohistiocytosis (HLH) is a macrophage activating syndrome that is known to develop in patients with autoimmune disease, malignancies or infection, for example with Epstein–Barr virus, cytomegalovirus or varicella zoster virus. We describe a 24‐month old boy with acute myelogenous leukaemia relapse and allogeneic bone marrow transplantation, who developed HLH on day +40 during chronic infection with norovirus. Here, we report for the first time the development of HLH in combination with chronic norovirus infection after allogeneic bone marrow transplantation in a hematopoietic malignancy. Copyright © 2013 John Wiley & Sons, Ltd.

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