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Hemophagocytic lymphohistiocytosis after allogeneic bone marrow transplantation during chronic norovirus infection
Author(s) -
Salvador Christina,
Meister Bernhard,
Larcher Heike,
Crazzolara Roman,
Kropshofer Gabriele
Publication year - 2014
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2052
Subject(s) - medicine , hemophagocytic lymphohistiocytosis , immunology , cytomegalovirus , malignancy , macrophage activation syndrome , bone marrow , bone marrow transplantation , transplantation , norovirus , virus , disease , virology , herpesviridae , viral disease , pathology , arthritis
Hemophagocytic lymphohistiocytosis (HLH) is a macrophage activating syndrome that is known to develop in patients with autoimmune disease, malignancies or infection, for example with Epstein–Barr virus, cytomegalovirus or varicella zoster virus. We describe a 24‐month old boy with acute myelogenous leukaemia relapse and allogeneic bone marrow transplantation, who developed HLH on day +40 during chronic infection with norovirus. Here, we report for the first time the development of HLH in combination with chronic norovirus infection after allogeneic bone marrow transplantation in a hematopoietic malignancy. Copyright © 2013 John Wiley & Sons, Ltd.