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Double‐delayed intensification paediatric protocol without radiotherapy is an efficient treatment in adult lymphoblastic lymphoma
Author(s) -
Corre Elise,
Marjanovic Zora,
Lapusan Simona,
Vekhoff Anne,
Hirsch Pierre,
Marie JeanPierre,
Legrand Ollivier
Publication year - 2012
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.2007
Subject(s) - medicine , lymphoblastic lymphoma , lymphoma , treatment protocol , radiation therapy , protocol (science) , pediatrics , overall survival , immunology , pathology , alternative medicine , immune system , t cell
Lymphoblastic lymphoma (LBL) is a rare disease associated with favourable prognosis in childhood but with poor prognosis in adults when treated with conventional non‐Hodgkin lymphoma regimens. Improvements in long‐term outcome have been made since the use of acute lymphoblastic leukaemia (ALL) regimens. We report here the feasibility of a double‐delayed intensification paediatric protocol in 12 adult LBL patients. There were no relapses and no deaths, with a median follow‐up of 4.7 years. Using the same protocol, overall survival was significantly longer in LBL patients versus ALL patients (100% vs 75%, p = 0.05). Overall tolerance was acceptable and better in ALL patients. We have shown the feasibility and the good results of using this paediatric protocol in LBL. Copyright © 2012 John Wiley & Sons, Ltd.