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Stevens–Johnson syndrome after lenalidomide therapy for multiple myeloma: a case report and a review of treatment options
Author(s) -
Allegra Alessandro,
Alonci Andrea,
Penna Giuseppa,
Russo Sabina,
Gerace Demetrio,
Greve Bruna,
D'Angelo Arianna,
Catena Sara,
Musolino Caterina
Publication year - 2012
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/hon.1000
Subject(s) - lenalidomide , medicine , multiple myeloma , bortezomib , allopurinol , bendamustine , thalidomide , dexamethasone , drug , dermatology , rituximab , oncology , pharmacology , lymphoma
Stevens‐ Johnson syndrome (SJS) is a severe and life‐threatening condition. Although allopurinol, an antihyperuricemia drug, is the drug most commonly associated with SJS, more than 100 different causative drugs have been reported. Among hematologic drugs recently introduced into the market, drugs such as rituximab, imatinib, and bortezomib are reported. Here, we describe a patient with SJS while receiving lenalidomide in combination with prednisolone for treatment‐naïve multiple myeloma. Although SJS has been reported rarely as an adverse reaction to Lenalidomide, this drug should be considered in the etiology of SJS, and the increased number of prescriptions of Lenalidomide for the therapy of multiple myeloma has to stress the awareness of its potentially serious side‐effects. Copyright © 2011 John Wiley & Sons, Ltd.