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Thyrocalcitonin III. Die Synthese des α‐Thyrocalcitonins: Vorläufige Mitteilung
Author(s) -
Rittel W.,
Brugger M.,
Kamber B.,
Riniker B.,
Sieber P.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.660510431
Subject(s) - chemistry , sulfoxide , trypsin , stereochemistry , methionine sulfoxide , hydrogen peroxide , derivative (finance) , methionine , biochemistry , enzyme , organic chemistry , financial economics , economics , amino acid
A synthesis of the dotriacontapeptide sequence I, reported by Neher et al. [1] for porcine α‐thyrocalcitonin (α‐TC), is described. The synthetic peptide is shown to be identical with α‐TC by thin layer chromatography and electrophoresis, by the pattern of trypsin degradation, and by its biological activity. Oxidation with hydrogen peroxide gave the methionine 25 sulfoxide derivative, which was identical with α‐TC‐sulfoxide (formerly called β‐thyrocalcitonin) from pig thyroids.