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Thyrocalcitonin. II. Struktur von α‐Thyrocalcitonin
Author(s) -
Neher R.,
Riniker B.,
Zuber H.,
Rittel W.,
Kahnt F. W.
Publication year - 1968
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.660510430
Subject(s) - chemistry , sulfoxide , methionine sulfoxide , methionine , residue (chemistry) , biochemistry , amino acid , stereochemistry , organic chemistry
The highly active peptide hormones isolated from pig thyroids – i.e. α‐thyrocalcitonin and its sulfoxide, containing 32 amino acid residues – were subjected to sequence studies using chemical and enzymatic methods. On the basis of these studies the following structure was derived for α‐thyrocalcitonin:In the α‐thyrocalcitonin sulfoxide (designated formerly as β‐thyrocalcitonin) the methionine residue is replaced by methionine sulfoxide.