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Mikrosynthese von 35 S‐markiertem Aneurin hoher spezifischer Aktivität
Author(s) -
Würsch J.
Publication year - 1958
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.660410109
Subject(s) - chemistry , yield (engineering) , specific activity , hydrochloride , chloride , nuclear chemistry , radiochemistry , medicinal chemistry , stereochemistry , chromatography , organic chemistry , enzyme , materials science , metallurgy
Aneurine‐ 35 S of high specific activity has been prepared following an industrial procedure based on the synthesis of Todd & Bergel . Starting from 3,0 mmoles of H 2 35 S of the specific activity 40,3 mc/mmole, 216 mg of aneurine chloride hydrochloride monohydrate corresponding to a chemical yield of 40,5% based on H 2 35 S has been obtained. It was pure as shown by paper chromatography and had a calculated specific activity of 110 μc/mg or 39,1 mc/mmole immediately after synthesis.