Nickel‐Catalyzed  Suzuki‐Miyaura  Cross‐Coupling Involving C−O Bond Activation | Zendy

Morishige Aoi | Zendy; Iyori Yasuaki | Zendy; Chatani Naoto | Zendy

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Nickel‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Involving C−O Bond Activation

Author(s) -

Morishige Aoi,

Iyori Yasuaki,

Chatani Naoto

Publication year - 2021

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.202100089

Subject(s) - chemistry , deprotonation , catalysis , aryl , amide , medicinal chemistry , nickel , coupling (piping) , peptide bond , coupling reaction , stereochemistry , ion , organic chemistry , mechanical engineering , alkyl , engineering , enzyme

An efficient Suzuki‐Miyaura cross‐coupling reaction of ortho ‐phenoxy‐substituted aromatic amides with aryl boronates is described. The use of LiO t Bu is crucial for the success of the reaction. An amidate anion, which is formed through deprotonation of the amide NH bond by LiO t Bu, functions as a directing group to activate a C−O bond.

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